Hematopoietic Stem Cell Transplantation in Elderly Patients with Myelodisplastic Syndrome and Acute Myelogenous Leukemia: Use of Busulfan/Fludarabine for Conditioning

摘要: Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are, typically, diseases of the elderly, with a 5–15% long-term survival rate prognosis that worsens beyond 60 years age. The is low, regardless chemotherapy regimen used. Bone marrow transplantation was traditionally not used in this age group, because high mortality due to conditioning regimen. However, leukemia-free lower recurrence rates can be improved immune therapy provided by reduced-intensity reduced-toxicity preparative allogeneic bone regimens, encouraging results studies using busulfan fludarabine. effective antileukemic effect cytoreduction, together immunological graft versus effect, disease control, leads us believe myeloablative without significant toxicity could successfully selected elderly patients.