Application of InterPro for the functional classification of the proteins of fish origin in SWISS-PROT and TrEMBL
作者： Margaret Biswas , Alex Kanapin , Rolf Apweiler
DOI: 10.1007/BF02703652
关键词: PROSITE 、 Structural Classification of Proteins database 、 Computational biology 、 UniProt 、 Protein family 、 InterPro 、 Genetics 、 Genome 、 Fish Proteins 、 Cytochrome b 、 Biology 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: InterPro (http://www.ebi.ac.uk/interpro/) is an integrated documentation resource for protein families, domains and sites, developed initially as a means of rationalizing the complementary efforts PROSITE, PRINTS, Pfam ProDom database projects. It useful that aids functional classification proteins. Almost 90% theactinopterygii sequences from SWISS-PROT TrEMBL can be classified using InterPro. Over 30% currently in are mitochondrial origin, majority which belong to cytochrome b/b6 family. also gives insights into domain composition proteins has applications newly determined lacking biochemical characterization, comparative genome analysis. A comparison against other eukaryotes confirms high representation eukaryotic kinase organisms studied. The comparisons show that, based on thetrans-species evolution MHC class I II molecules mammals teleost fish recognized.
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