Gene–gene and gene–environment interactions on IgE production in prenatal stage

摘要: To cite this article: Yang KD, Chang J-C, Chuang H, Liang H-M, Kuo H-C, Lee Y-S, Hsu T-Y, Ou C-Y. Gene–gene and gene–environment interactions on IgE production in prenatal stage. Allergy 2010; 65: 731–739. Abstract Background:  Prevalence of allergic diseases children has increased worldwide over the past decades. sensitization may occur fetal life. This study investigated whether gene–gene affected cord blood (CBIgE) levels. Methods:  A total 575 DNA samples were subjected to a multiplex microarray for 384 single nucleotide polymorphisms (SNPs) 159 allergy candidate genes. Genetic association was initially assessed by univariate multivariate analyses. Multifactor dimensionality reduction (MDR) used identify interactions. Environmental factors analysis included maternal atopy, paternal parental smoking, gender, prematurity. Results:  Twenty-one SNPs 14 genes associated with CBIgE elevation (≥0.5 KU/l) analysis. Multivariate identified eleven (IL13, IL17A, IL2RA, CCL17, CXCL1, PDGFRA, FGF1, HAVCR1, GNAQ, C11orf72, ADAM33) which significantly elevation. MDR analyses IL13 interacted IL17A and/or redox prediction accuracy 62.52%. Analyses that atopy combined IL13, rs1800925 CCL22, rs170359 had highest 67.15%. All high low risk classifications could be validated Chi-square test. Conclusions:  (e.g. immune genes) FGF1or begin stage, suggesting prevention IgE-mediated made possible control responses