Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children

摘要: Background. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the outcome. The aim this study was investigate CLEC5A (C-type lectin domain family 5) polymorphisms regards outcome KD. Methods. A total 1045 subjects (381 patients 664 controls) were enrolled identify 4 tagging single-nucleotide (tSNPs) (rs1285968, rs11770855, rs1285935, rs1285933) using TaqMan Allelic Discrimination Assay. Hardy-Weinberg equilibrium assessed cases controls, effects evaluated chi-square test. Results. No significant associations noted between genotypes allele frequency tSNPs controls patients. In patients, showed no association lesion formation intravenous immunoglobulin treatment response. Conclusions. This for first time that not KD, formation, a Taiwanese population.