The exocyst is a Ral effector complex
作者： Serge Moskalenko , Dale O. Henry , Carine Rosse , Gladys Mirey , Jacques H. Camonis
DOI: 10.1038/NCB728
关键词: Ral GTP-Binding Proteins 、 GTPase 、 Exocytosis 、 Ral Guanine Nucleotide Exchange Factor 、 RALA 、 Cell polarity 、 Cell biology 、 Exocyst 、 Chemistry 、 RALB
摘要: Delivery of cytoplasmic vesicles to discrete plasma-membrane domains is critical for establishing and maintaining cell polarity, neurite differentiation regulated exocytosis. The exocyst a multisubunit complex required vectorial targeting subset secretory vesicles. Mechanisms that regulate the activity this in mammals are unknown. Here we show Sec5, an integral component exocyst, direct target activated Ral GTPases. GTPases basolateral proteins epithelial cells, secretagogue-dependent exocytosis neuroendocrine cells assembly complexes. These observations define as regulators vesicle trafficking.
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