Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats

摘要: Acrylamide (AA) is a heat-induced toxin formed during thermal processing of many commonly consumed foods, including meat products, French fries, potato crisps, bread, cereals, cookies, and coffee. There thus potentially high dietary exposure humans to AA, which can induce significant oxidative stress. Hesperidin (HS) diosmin (DS) are flavone glycosides that have antioxidant properties. The aim this study was investigate the protective effects HS DS against AA toxicity. Fifty-six adult male Wistar albino rats were divided into seven groups. first group orally administered 0.5% (w/v) dimethyl sulfoxide (DMSO) considered as control group. second third groups 10 mg/kg/day or DS, respectively. fourth received 20 for 14 days. fifth sixth given respectively, followed by AA. seventh both after administration. intoxication significantly (p ≤ 0.05) increased serum levels liver function enzymes (ALT, AST, ALP), kidney products (urea creatinine), DNA damage marker (OHdG), proinflammatory markers (TNF-α, IL-1β, IL-6), lipid peroxidation (malondialdehyde), nitric oxide (NO). On other hand, it decreased reduced glutathione (GSH) in liver, kidney, brain. activities peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) brain tissues also reduced. supplementation prevented peroxidation, normalized parameters altered enhanced tissue concentrations biomarkers. It could be concluded potent stress, induced toxicity rats.