Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism
作者： Jonathon Hull , Marcela Usmari Moraes , Emma Brookes , Seth Love , Myra E. Conway
DOI: 10.1016/J.NEUINT.2017.10.014
关键词: Astrocyte 、 Human brain 、 Amino acid 、 Glutamate receptor 、 Glutamatergic 、 Biochemistry 、 Excitotoxicity 、 Glutamate dehydrogenase 、 Glutamine synthetase 、 Biology
摘要: … These proteins mediate the transfer of the α-amino group from the BCAA to α-ketoglutarate to produce glutamate and the respective branched-chain α-keto acid (BCKA – …
uwe.ac.uk
core.ac.uk
sci-hub.se 参考文章(68)
Jonathon Hull, Vinood Patel, Maya El Hindy, Christopher Lee, Esther Odeleye, Mohammed Hezwani, Seth Love, Patrick Kehoe, Katy Chalmers, Myra Conway, Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity Journal of Alzheimer's Disease. ,vol. 45, pp. 891- 905 ,(2015) , 10.3233/JAD-142970
Erich Lieth, Kathryn F. LaNoue, Deborah A. Berkich, Baiyang Xu, Michael Ratz, Charles Taylor, Susan M. Hutson, Nitrogen shuttling between neurons and glial cells during glutamate synthesis. Journal of Neurochemistry. ,vol. 76, pp. 1712- 1723 ,(2001) , 10.1046/J.1471-4159.2001.00156.X
K.M. Popov, Y Zhao, Y Shimomura, M.J. Kuntz, R.A. Harris, Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases. Journal of Biological Chemistry. ,vol. 267, pp. 13127- 13130 ,(1992) , 10.1016/S0021-9258(18)42179-5
Z. Damuni, L.J. Reed, Purification and properties of the catalytic subunit of the branched-chain alpha-keto acid dehydrogenase phosphatase from bovine kidney mitochondria. Journal of Biological Chemistry. ,vol. 262, pp. 5129- 5132 ,(1987) , 10.1016/S0021-9258(18)61164-0
Jonathon Hull, Vinood B. Patel, Susan M. Hutson, Myra E. Conway, New insights into the role of the branched‐chain aminotransferase proteins in the human brain Journal of Neuroscience Research. ,vol. 93, pp. 987- 998 ,(2015) , 10.1002/JNR.23558
A Suryawan, J W Hawes, R A Harris, Y Shimomura, A E Jenkins, S M Hutson, A molecular model of human branched-chain amino acid metabolism. The American Journal of Clinical Nutrition. ,vol. 68, pp. 72- 81 ,(1998) , 10.1093/AJCN/68.1.72
Jakob D. Nissen, Kamilla Pajęcka, Malin H. Stridh, Dorte M. Skytt, Helle S. Waagepetersen, Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes Glia. ,vol. 63, pp. 2313- 2326 ,(2015) , 10.1002/GLIA.22895
Gulnur Sh Burbaeva, Marina S Turishcheva, Elena A Vorobyeva, Olga K Savushkina, Elena B Tereshkina, Irina S Boksha, Diversity of glutamate dehydrogenase in human brain. Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 26, pp. 427- 435 ,(2002) , 10.1016/S0278-5846(01)00273-1
Mohammad Mainul Islam, Manisha Nautiyal, R Max Wynn, James A Mobley, David T Chuang, Susan M Hutson, None, Branched-chain Amino Acid Metabolon INTERACTION OF GLUTAMATE DEHYDROGENASE WITH THE MITOCHONDRIAL BRANCHED-CHAIN AMINOTRANSFERASE (BCATm) Journal of Biological Chemistry. ,vol. 285, pp. 265- 276 ,(2010) , 10.1074/JBC.M109.048777
F. Rothe, M. Brosz, J. Storm-Mathisen, Quantitative ultrastructural localization of glutamate dehydrogenase in the rat cerebellar cortex Neuroscience. ,vol. 64, pp. 1133- 1146 ,(1995) , 10.1016/0306-4522(94)E0200-N