A luminescent sensor for tyrosine phosphorylation.
作者： Matthew S. Tremblay , Minhee Lee , Dalibor Sames
DOI: 10.1021/OL701920X
关键词: Peptide sequence 、 Protein tyrosine phosphatase 、 Biophysics 、 Chemistry 、 Biochemistry 、 Moiety 、 Luminescence 、 Kinase activity 、 Tyrosine phosphorylation 、 Protein phosphorylation 、 Phosphorylation
摘要: We have developed a luminogenic probe for tyrosine phosphorylation based on short peptide sequence containing an iminodiacetate moiety near the site of phosphorylation. In response to kinase activity, provides strong luminescence enhancement, resulting from increased ability bind and sensitize Tb3+ Eu3+ ions upon
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