Upregulation of CASC2 sensitized glioma to temozolomide cytotoxicity through autophagy inhibition by sponging miR-193a-5p and regulating mTOR expression.
作者： Chunming Jiang , Fang Shen , Jianmin Du , Xiang Fang , Xiaoli Li
DOI: 10.1016/J.BIOPHA.2017.10.146
关键词: Viability assay 、 Cancer research 、 Temozolomide 、 Glioma 、 Cell biology 、 PI3K/AKT/mTOR pathway 、 Downregulation and upregulation 、 Apoptosis 、 Autophagy 、 Chemistry 、 Cell culture
摘要: … Numerous studies suggested autophagy was involved in temozolomide (TMZ) resistance in glioma. Long non-coding RNA (lncRNA) CASC2 was shown to be downregulated in glioma …
sci-hub.se 参考文章(35)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
O. Khorkova, J. Hsiao, C. Wahlestedt, Basic biology and therapeutic implications of lncRNA. Advanced Drug Delivery Reviews. ,vol. 87, pp. 15- 24 ,(2015) , 10.1016/J.ADDR.2015.05.012
Jeremy E. Wilusz, Long noncoding RNAs: Re-writing dogmas of RNA processing and stability. Biochimica et Biophysica Acta. ,vol. 1859, pp. 128- 138 ,(2016) , 10.1016/J.BBAGRM.2015.06.003
Yusuke S. Hori, Ryusuke Hosoda, Yukinori Akiyama, Rio Sebori, Masahiro Wanibuchi, Takeshi Mikami, Toshiya Sugino, Kengo Suzuki, Mitsuhisa Maruyama, Miki Tsukamoto, Nobuhiro Mikuni, Yoshiyuki Horio, Atsushi Kuno, Chloroquine potentiates temozolomide cytotoxicity by inhibiting mitochondrial autophagy in glioma cells. Journal of Neuro-oncology. ,vol. 122, pp. 11- 20 ,(2015) , 10.1007/S11060-014-1686-9
John R Prensner, Matthew K Iyer, Anirban Sahu, Irfan A Asangani, Qi Cao, Lalit Patel, Ismael A Vergara, Elai Davicioni, Nicholas Erho, Mercedeh Ghadessi, Robert B Jenkins, Timothy J Triche, Rohit Malik, Rachel Bedenis, Natalie McGregor, Teng Ma, Wei Chen, Sumin Han, Xiaojun Jing, Xuhong Cao, Xiaoju Wang, Benjamin Chandler, Wei Yan, Javed Siddiqui, Lakshmi P Kunju, Saravana M Dhanasekaran, Kenneth J Pienta, Felix Y Feng, Arul M Chinnaiyan, The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex Nature Genetics. ,vol. 45, pp. 1392- 1403 ,(2013) , 10.1038/NG.2771
Vishnu Anand Cuddapah, Stefanie Robel, Stacey Watkins, Harald Sontheimer, A neurocentric perspective on glioma invasion Nature Reviews Neuroscience. ,vol. 15, pp. 455- 465 ,(2014) , 10.1038/NRN3765
YUAN ZHOU, HAN-DONG WANG, LIN ZHU, ZI-XIANG CONG, NING LI, XIANG-JUN JI, HAO PAN, JIA-WEI WANG, WAN-CHUN LI, Knockdown of Nrf2 enhances autophagy induced by temozolomide in U251 human glioma cell line Oncology Reports. ,vol. 29, pp. 394- 400 ,(2013) , 10.3892/OR.2012.2115
Florence Lefranc, Niloufar Sadeghi, Isabelle Camby, Thierry Metens, Olivier Dewitte, Robert Kiss, Present and potential future issues in glioblastoma treatment. Expert Review of Anticancer Therapy. ,vol. 6, pp. 719- 732 ,(2006) , 10.1586/14737140.6.5.719
George A. Calin, Carlo M. Croce, MicroRNA signatures in human cancers Nature Reviews Cancer. ,vol. 6, pp. 857- 866 ,(2006) , 10.1038/NRC1997
Wolfgang Wick, Michael Platten, Understanding and Targeting Alkylator Resistance in Glioblastoma Cancer Discovery. ,vol. 4, pp. 1120- 1122 ,(2014) , 10.1158/2159-8290.CD-14-0918