Dynamic Contrast-Enhanced MRI of Prostate Cancer at 3 T: A Study of Pharmacokinetic Parameters

作者: Iclal Ocak , Marcelino Bernardo , Greg Metzger , Tristan Barrett , Peter Pinto

DOI: 10.2214/AJR.06.1329

关键词: RadiologyPredictive valueProspective cohort studyDynamic contrast-enhanced MRIProstate cancerEndorectal coilProstateBiopsyMedicinePharmacokinetics

摘要: OBJECTIVE. The objectives of our study were to determine whether dynamic contrast-enhanced MRI performed at 3 T and analyzed using a pharmacokinetic model improves the diagnostic performance for detection prostate cancer compared with conventional T2-weighted imaging, which parameters are useful in diagnosing cancer.SUBJECTS AND METHODS. This prospective included 50 consecutive patients biopsy-proven who underwent imaging on 3-T scanner combination sensitivity-encoding (SENSE) cardiac coil an endorectal coil. Scans obtained least 5 weeks after biopsy. turbo spin-echo images three planes, acquired during single-dose bolus injection gadopentetate dimeglumine (0.1 mmol/kg). Sensitivity, specificity, positive predictive value (PPV), negative (NPV) estimated c...

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