Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10
作者： Wakako Fujita , Ivone Gomes , Lakshmi A Devi
DOI: 10.1111/BPH.12798
关键词: Cannabinoid 、 Pharmacology 、 Opioid 、 G protein-coupled receptor 、 Heteromer 、 Metabotropic receptor 、 Neuroscience 、 Receptor 、 Rhodopsin-like receptors 、 Opioid receptor 、 Chemistry
摘要: GPCRs can interact with each other to form homomers or heteromers. Homomers involve interactions the same receptor type while heteromers between two different GPCRs. These receptor–receptor modulate not only binding but also signalling and trafficking properties of individual receptors. Opioid heteromerization has been extensively investigated objective identifying novel therapeutic targets that are as potent morphine without side effects associated chronic use. In this context, studies have described types opioid receptors a wide range including adrenoceptors, cannabinoid, 5-HT, metabotropic glutamate sensory neuron-specific Recent advances in field involving generation heteromer-specific reagents (antibodies ligands) membrane-permeable peptides disrupt heteromer interaction helping elucidate physiological role contribution partner For example, using targeting interface implicated μ δ development tolerance morphine, gastrin-releasing peptide morphine-induced itch. addition, number ligands selectively target exhibit antinociception decrease commonly review, we summarize latest findings regarding biological functional characteristics both vitro vivo.
sci-hub.se 参考文章(125)
R. P. Xiao, S. Pepe, H. A. Spurgeon, M. C. Capogrossi, E. G. Lakatta, Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 272, ,(1997) , 10.1152/AJPHEART.1997.272.2.H797
Ivone Gomes, Wakako Fujita, Moraje V. Chandrakala, Lakshmi A. Devi, Disease-Specific Heteromerization of G-Protein-Coupled Receptors That Target Drugs of Abuse Progress in Molecular Biology and Translational Science. ,vol. 117, pp. 207- 265 ,(2013) , 10.1016/B978-0-12-386931-9.00009-X
Carl Rios, Ivone Gomes, Lakshmi A Devi, μ
opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis British Journal of Pharmacology. ,vol. 148, pp. 387- 395 ,(2006) , 10.1038/SJ.BJP.0706757
Annabelle Reaux, Nadia De Mota, Ivana Skultetyova, Zsolt Lenkei, Said El Messari, Katalin Gallatz, Pierre Corvol, Miklos Palkovits, Catherine Llorens-Cortès, Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain Journal of Neurochemistry. ,vol. 77, pp. 1085- 1096 ,(2001) , 10.1046/J.1471-4159.2001.00320.X
Stephen P.H. Alexander, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Joanna L. Sharman, Michael Spedding, John A. Peters, Anthony J. Harmar, , The Concise Guide to PHARMACOLOGY 2013/14: Enzymes British Journal of Pharmacology. ,vol. 170, pp. 1797- 1867 ,(2013) , 10.1111/BPH.12451
S SUZUKI, L CHUANG, P YAU, R DOI, R CHUANG, Interactions of Opioid and Chemokine Receptors: Oligomerization of , and with CCR5 on Immune Cells Experimental Cell Research. ,vol. 280, pp. 192- 200 ,(2002) , 10.1006/EXCR.2002.5638
Hung-Li Wang, Chia-Yu Hsu, Pei-Chen Huang, Yo-Li Kuo, Allen H. Li, Tu-Hsueh Yeh, An-Swe Tso, Ying-Ling Chen, Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist. Journal of Neurochemistry. ,vol. 92, pp. 1285- 1294 ,(2005) , 10.1111/J.1471-4159.2004.02921.X
Laura S. Stone, Leigh B. MacMillan, Kelley F. Kitto, Lee E. Limbird, George L. Wilcox, The α2a Adrenergic Receptor Subtype Mediates Spinal Analgesia Evoked by α2 Agonists and Is Necessary for Spinal Adrenergic–Opioid Synergy The Journal of Neuroscience. ,vol. 17, pp. 7157- 7165 ,(1997) , 10.1523/JNEUROSCI.17-18-07157.1997
Bryen A. Jordan, Lakshmi A. Devi, G-protein-coupled receptor heterodimerization modulates receptor function Nature. ,vol. 399, pp. 697- 700 ,(1999) , 10.1038/21441
B. A. Jordan, I. Gomes, C Rios, J. Filipovska, L. A. Devi, Functional Interactions between μ Opioid and α2A-Adrenergic Receptors Molecular Pharmacology. ,vol. 64, pp. 1317- 1324 ,(2003) , 10.1124/MOL.64.6.1317