Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria
作者： J.P. Kamat , T.P.A. Devasagayam
DOI: 10.1016/0304-3940(95)11812-B
关键词: Radical initiator 、 Mitochondrion 、 In vitro 、 Protein oxidation 、 Biochemistry 、 Lipid peroxidation 、 Central nervous system 、 Alpha (ethology) 、 Biology 、 Antioxidant
摘要: The tocotrienol-rich-fraction (TRF) from palm oil, being tried as a more economical and efficient substitute for alpha-tocopherol, significantly inhibited oxidative damage in vitro to both lipids proteins rat brain mitochondria induced by ascorbate-Fe2+, the free radical initiator azobis(2-amidopropane)dihydrochloride (AAPH) photosensitisation. observed inhibitory effect was time- concentration-dependent. At low concentration of 5 microM, TRF can inhibit proteins. seems be mainly due gamma-tocotrienol lesser extent alpha- delta-tocotrienols. effective than alpha-tocopherol. This fraction oil considered natural antioxidant supplement capable protecting against thereby ensuing adverse alterations.
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