Dehydroepiandosterone induction of increased resistance to vancomycin in Staphylococcus aureus clinical isolates (MSSA, MRSA)
作者： B.J. Plotkin , A. Morejon , R.A. Laddaga , S.M. Viselli , J. Tjhio
DOI: 10.1111/J.1472-765X.2005.01665.X
关键词: Genotypic resistance 、 Micrococcaceae 、 Vancomycin 、 Bacteria 、 Dehydroepiandrosterone 、 Antibiotics 、 Androgen 、 Biology 、 Microbiology 、 Staphylococcus aureus
摘要: B.J. PLOTKIN, A. MOREJON, R.A. LADDAGA, S.M. VISELLI, J. TJHIO AND P. SCHRECKENBERGER. 2005. Aims: To investigate whether dehydroepiandosterone (DHEA), an androgen present throughout life, alters the response of Staphylococcus aureus clinical isolates to vancomycin. Methods and Results: DHEA in physiologically relevant concentrations (0AE1, 0AE5, 1AE0 5AE0 lmol l )1 ) was tested for its effect on methicillin-sensitive S. (MSSA, n ¼ 53) methicillin-resistant (MRSA, 73) vancomycin using standard protocols. Mutant selection determined by serial transfer selected (n 5). DHEA-mediated at least a fourfold increase MIC 42% MSSA 21% MRSA. For five (0AE1 0AE5 DHEA) increased levels (8 gm defined as vancomycin-intermediate resistance. Conclusion: Resistance detected only presence DHEA, not related altered generation time, indicating induction phenotypic Significance Impact Study: These findings require further investigation determine what role plays treatment failure that has been reported absence genotypic resistance or heteroresistance. 1
unirioja.es
sci-hub.se 参考文章(39)
S. Kliesch, Hormontherapie des alternden Mannes Urologe A. ,vol. 43, pp. 1087- 1091 ,(2004) , 10.1007/S00120-004-0657-8
Robbins M, Rogers T, McKnight Jt, Rodman Dp, The appropriateness of initial vancomycin dosing. Journal of Family Practice. ,vol. 38, pp. 473- 477 ,(1994)
Mary Jane. Ferraro, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically NCCLS. ,(2000)
Karen I. Plaisance, Brian G. Katona, Anthony E. Zimmermann, Association of Vancomycin Serum Concentrations With Outcomes in Patients With Gram‐Positive Bacteremia Pharmacotherapy. ,vol. 15, pp. 85- 91 ,(1995) , 10.1002/J.1875-9114.1995.TB04335.X
Benriques Henriques Normark, S. Normark, Antibiotic tolerance in pneumococci Clinical Microbiology and Infection. ,vol. 8, pp. 613- 622 ,(2002) , 10.1046/J.1469-0691.2002.00477.X
Keiichi Hiramatsu, Vancomycin resistance in staphylococci. Drug Resistance Updates. ,vol. 1, pp. 135- 150 ,(1998) , 10.1016/S1368-7646(98)80029-0
James H. Ludens, James R. DeVries, Darrell D. Fanestil, Studies on affinity chromatography of aldosterone-binding macromolecules. Journal of Steroid Biochemistry. ,vol. 3, pp. 193- 200 ,(1972) , 10.1016/0022-4731(72)90050-7
A. Tarasi, M. Cassone, M. Monaco, D. Tarasi, M.E. Pompeo, M. Venditti, Activity of Moxifloxacin in Combination with Vancomycin or Teicoplanin against Staphylococcus aureus Isolated from Device-Associated Infections Unresponsive to Glycopeptide Therapy Journal of Chemotherapy. ,vol. 15, pp. 239- 243 ,(2003) , 10.1179/JOC.2003.15.3.239
Wiebke Arlt, Dehydroepiandrosterone and ageing. Best Practice & Research Clinical Endocrinology & Metabolism. ,vol. 18, pp. 363- 380 ,(2004) , 10.1016/J.BEEM.2004.02.006
Hyunchul Jo, Hyun Jeong Ahn, Eun Mi Kim, Hee Joong Kim, Sang Cheol Seong, InBum Lee, Myung Chul Lee, Effects of dehydroepiandrosterone on articular cartilage during the development of osteoarthritis. Arthritis & Rheumatism. ,vol. 50, pp. 2531- 2538 ,(2004) , 10.1002/ART.20368