Relation between glutamine, branched-chain amino acids, and protein metabolism.

作者: Milan Holeček

DOI: 10.1016/S0899-9007(01)00767-5

关键词: Amino acidValineAlanineBiochemistryCatabolismGlutamineMetabolismInternal medicineProtein metabolismLeucineEndocrinologyBiology

摘要: The branched-chain amino acids (BCAAs; valine, isoleucine, and leucine) are the major nitrogen source for glutamine alanine synthesis in muscle. Synthesis of glutamine, alanine, BCAA use is activated critical illnesses such as sepsis, cancer, trauma. often exceeds its synthesis, resulting lack plasma tissues. In illness, resynthesis from keto activated, particularly hepatic tissue. released to circulation may be used protein or glutamine. Glutamine and/or infusion has an inhibitory effect on breakdown body proteins decreases catabolism postabsorptive control, endotoxemic, irradiated rats. Decreased also was observed when by ammonia infusion. conclusion some favorable effects supply can explained role positive exogenous metabolism BCAA.

参考文章(32)
P A King, L Goldstein, E A Newsholme, Glutamine synthetase activity of muscle in acidosis. Biochemical Journal. ,vol. 216, pp. 523- 525 ,(1983) , 10.1042/BJ2160523
A E Harper, S M Hutson, T C Cree, Regulation of leucine and alpha-ketoisocaproate metabolism in skeletal muscle. Journal of Biological Chemistry. ,vol. 253, pp. 8126- 8133 ,(1978) , 10.1016/S0021-9258(17)34371-5
M. B. Heyman, General and specialized parenteral amino acid formulations for nutrition support. Journal of The American Dietetic Association. ,vol. 90, pp. 401- 408 ,(1990)
L. Hagenfeldt, S. Eriksson, J. Wahren, Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects. Clinical Science. ,vol. 59, pp. 173- 181 ,(1980) , 10.1042/CS0590173
A. J. M. Wagenmakers, P. B. Soeters, L. A. Cynober, Metabolism of branched-chain amino acids. CRC Press Inc.. pp. 67- 87 ,(1995)
Neil B. Ruderman, Michael Berger, The Formation of Glutamine and Alanine in Skeletal Muscle Journal of Biological Chemistry. ,vol. 249, pp. 5500- 5506 ,(1974) , 10.1016/S0021-9258(20)79756-5
J. C. Waterlow, J. M. L. Stephen, Rank Prize Funds, Nitrogen metabolism in man. Nitrogen metabolism in man.. ,(1981)
M D Nawabi, K P Block, M C Chakrabarti, M G Buse, Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain alpha-keto acid dehydrogenase. Journal of Clinical Investigation. ,vol. 85, pp. 256- 263 ,(1990) , 10.1172/JCI114421