Transcriptional Regulation of the α-fetoprotein Gene by SWI/SNF Chromatin Remodeling Complex
作者： Katsuhide Miyake , Mikio Takahashi , Takeaki Dohda , Hidenori Kaneoka , Yoshitaka Sato
DOI: 10.1007/S10616-006-6702-2
关键词: Chromatin remodeling 、 Transactivation 、 Transcription factor 、 Transcriptional regulation 、 Biology 、 Chromatin 、 SWI/SNF 、 Ccaat-enhancer-binding proteins 、 Molecular biology 、 Coactivator
摘要: α-Fetoprotein (AFP) is a fetal serum protein abundant in liver whose expression downregulated adult liver. The promoter–proximal region of the AFP gene contains two binding sites for CCAAT/enhancer-binding α (C/EBPα), hepatocyte nuclear factor-1α (HNF-1α) and one factor-1 (NF-1). Luciferase reporter assays showed that combination C/EBPα, HNF-1α, NF-1 coactivator p300 gave maximal activity but BRG1 BRM, ATPase subunit chromatin remodeling complex SWI/SNF, repressed transactivation by these transcription factors. Deletion analyses C/EBPα suggested recruited SWI/SNF caused repression. This repression may also play important roles downregulation hepatocytes.
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