The influence of vitamin E supplementation on erythropoietin responsiveness in chronic hemodialysis patients with low levels of erythrocyte superoxide dismutase

摘要: About 12-15 % of hemodialysis patients have a poor response to recombinant human erythropoietin (rHuEPO). The aim this prospective study was examine the influence oxidative stress and vitamin E supplementation on rHuEPO responsiveness in chronic patients. Sixty-five treated with were studied. Those iron deficiency, blood loss, malignancy, B12 folate severe hyperparathyroidism, liver cirrhosis, congestive heart failure excluded. Twenty-one healthy volunteers served as control group. Malondialdehyde, carbonyl proteins, erythrocyte superoxide dismutase (SOD), ceruloplasmin, serum antioxidant capacity measured. Values SOD > 150 U/ml considered normal. Patients 200. positively correlated hemoglobin (p = 0.0018, R 0.337) negatively index 0.0122, 0.319). Vitamin E-treated from group A exhibited significantly increased levels compared initial values (10.5 ± 0.3 vs. 8.6±0.4, p 0.002). In comparison B, displayed higher 9.4 0.3, 0.04), had lower dose (85.7 7.4 136.8 13.8, 0.025), improved (rHuEPO 177.9 28.6 314.1 34.0, 0.006). their after therapy baseline 271.7 30.3, 0.034). We conclude that correlate hemoglobin, improves responsiveness, increases level, decreases dose.