Lectin Histochemistry of Resected Adenocarcinoma of the Lung : Helix pomatia Agglutinin Binding Is an Independent Prognostic Factor

摘要: The worldwide incidence of adenocarcinoma the lung is rising. Unfortunately, no significant prognostic marker beyond classical TNM staging exists to stratify these patients for appropriate therapy. Because lectins, carbohydrate-binding proteins, have been shown be useful markers in several other adenocarcinomas, a panel lectins [ Helix pomatia gglutinin (HPA), Phaseolus vulgaris leukoagglutinin, Ulex europaeus agglutinin, Maackia amurenis Sambucus nigra agglutinin] with different specificities were tested their relevance. Paraffin wax sections 93 adenocarcinomas who had undergone surgery between 1990 and 1995 investigated by lectin histochemistry. Lectin-binding data known factors correlated survival. In univariate analysis, binding HPA, agglutinin cells indicators overall relapse-free survival, whereas value. However, multivariate analysis next stage gender only HPA was independent factor on conclusion, primary marker-based predictor prognosis our patient population allows into low- high-risk group.