Dysfunction of the RB Retinoblastoma Gene in Cancer

摘要: The retinoblastoma gene RB, which was the first tumor suppressor to be identified, is a key regulator of cell cycle and its inactivation, either direct or indirect, underlies multiple types human tumors. Consistent with role as suppressor, it well established that RB inhibits proliferation by binding E2F family transcription factors thereby repressing genes are required for G1–S transition cycle. However, in past decade, myriad studies focusing on cancer development implicated many cellular processes could all contribute function, suggesting much more complex than previously thought. To further complicate matters, other members family, retinoblastoma-like 1 (RBL1 p107) 2 (RBL2 p130), have both overlapping distinct functions compared mediated over hundred interacting proteins numerous transcriptional targets. Now, emerging evidence shows status can influence response different anti-cancer therapeutics according context. Therefore, thorough understanding crucial ever.