RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy

摘要: // Paola Indovina 1, 2 , Francesca Pentimalli 3 Nadia Casini Immacolata Vocca Antonio Giordano 1 Sbarro Institute for Cancer Research and Molecular Medicine, Center Biotechnology, College of Science Technology, Temple University, Philadelphia, PA, USA Department Surgery Neuroscience, University Siena Istituto Toscano Tumori (ITT), Siena, Italy Oncology Mercogliano (CROM), Nazionale “Fodazione G. Pascale” – IRCCS, Naples, Correspondence to: Giordano, e-mail: giordano@temple.edu Keywords: RB family, apoptosis, E2F, cancer therapy, CDK inhibitors Received: May 14, 2015      Accepted: June 06, Published: 18, 2015 ABSTRACT Inactivation the retinoblastoma (RB1) tumor suppressor is one most frequent early recognized molecular hallmarks cancer. RB1, although mainly studied its role in regulation cell cycle, emerged as a key regulator many biological processes. Among these, RB1 has been implicated alteration which underlies both development resistance to therapy. however, still controversial because, depending on context, apoptotic cues, own status, can act either by inhibiting or promoting apoptosis. Moreover, mechanisms whereby controls proliferation apoptosis coordinated manner are only now beginning be unraveled. Here, reviewing main studies assessing effect status modulation these processes, we provide an overview possible underlying family members, dictate fate various contexts. We also describe current antitumoral strategies aimed at use predictive, prognostic therapeutic target A thorough understanding function controlling determination crucial successful translation assessment clinical setting.