HUH site-specific recombinases for targeted modification of the human genome
作者： Coral González-Prieto , Leticia Agúndez , Ralph Michael Linden , Matxalen Llosa
DOI: 10.1016/J.TIBTECH.2013.02.002
关键词: Recombinase 、 Computational biology 、 Viral vector 、 Protein family 、 Genome 、 Human genome 、 Genetics 、 Zinc finger nuclease 、 Site-specific recombination 、 Gene delivery 、 Biology
摘要: Site-specific recombinases (SSRs) have been crucial in the development of mammalian transgenesis. For gene therapy purposes, this approach remains challenging, because, for example, SSR delivery is largely unresolved and DNA substrates must pre-exist target cells. In review, we discuss potential His-hydrophobic-His (HUH) to overcome some limitations conventional SSRs. Members HUH protein family cleave single-stranded (ss)DNA, but can mediate site-specific integration with aid host replication machinery. Adeno-associated virus (AAV) Rep only known example support human cells, AAV an excellent vector that be targeted specific cells organelles. Bacterial TrwC catalyzes into sequences delivered covalently linked DNA, offering attractive new features genome modification.
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