Size dependent induction of proinflammatory cytokines and cytotoxicity of particulate beta-tricalciumphosphate in vitro
作者： Tobias Lange , Arndt F. Schilling , Fabian Peters , Jan Mujas , Daniel Wicklein
DOI: 10.1016/J.BIOMATERIALS.2011.02.039
关键词: Molecular biology 、 In vitro 、 Biochemistry 、 Peripheral blood mononuclear cell 、 Biology 、 Lactate dehydrogenase 、 Cytokine 、 Context (language use) 、 Particle size 、 Proinflammatory cytokine 、 Cytotoxicity 、 Biophysics 、 Mechanics of Materials 、 Bioengineering 、 Biomaterials 、 Ceramics and Composites
摘要: Cellular responses to particulate calcium phosphate ceramics can lead inflammatory reactions under certain conditions that depend on particle composition, size and morphology. In this context, the potential influence of varying sizes beta-tricalciumphosphate (beta-TCP) induction inflammation cytotoxicity remains be determined. The present work investigates effects beta-TCP particles five different (1, 3, 13, 32 40 μm) human peripheral blood mononuclear cells (PBMC) in vitro concerning release TNF-alpha, IL-1beta IL-8 after six 18 h incubation (ELISA) as well intracellular IFN-gamma, IL-1alpha, levels within distinct PBMC subpopulations 12 (FACS). Potential cytotoxic were determined by assaying lactate dehydrogenase (LDH) morphological analyses (electron microscopy). Beta-TCP 1 μm did not induce any cytokine 6 but slightly increases h. Larger (32 consistently caused higher increasing fraction producing monocytes. They also LDH smaller, phagocytosable particles. These data suggest a less profile devices with smaller primary when compared larger
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