What can rodent models tell us about apathy and associated neuropsychiatric symptoms in Parkinson's disease?

摘要: In addition to classical motor symptoms, Parkinson's disease (PD) patients display incapacitating neuropsychiatric manifestations, such as apathy, anhedonia, depression and anxiety. These hitherto generally neglected non-motor have gained increasing interest in medical scientific communities over the last decade because of extent their negative impact on PD patients' quality life. Although recent clinical functional imaging studies provided useful information, pathophysiology apathy associated affective impairments remains elusive. Our aim this review is summarize discuss advances development rodent models PD-related symptoms using neurotoxin lesion-based approaches. The data collected suggest that bilateral partial lesions nigrostriatal system aimed at inducing reliable neuropsychiatric-like deficits while avoiding severe may interfere with behavioral evaluation, a more selective efficient strategy than medial forebrain bundle lesions. Moreover, all different classes pharmacological agents, D2/D3 receptor agonists pramipexole appear be most treatment for wide range induced by dopaminergic Lesion-based models, therefore, relevant tools studying PD. Data accumulated so far confirm causative role depletion, especially system, related They also put forward receptors potential targets