Serodiagnosis of viral hepatitis A by a solid-phase radioimmunoassay specific for IgM antibodies.
作者： Bengt G. Hansson , Jean K. Calhoun , Doris C. Wong , Stephen M. Feinstone , Robert H. Purcell
DOI: 10.1080/00365548.1981.11690359
关键词: Immunology 、 Hepatitis 、 Antigen 、 Elevated transaminases 、 Outbreak 、 Antibody 、 Radioimmunoassay 、 Viral hepatitis 、 Hepatitis A 、 Virology 、 Medicine
摘要: AbstractA solid-phase radioimmunoassay for detecting specific IgM antibodies to hepatitis A virus (HAV) was developed and characterized. The test utilizes microtiter plates coated with anti-IgM specifically absorb the from serum. anti-hepatitis are measured by consecutive binding of antigen radiolabeled (anti-HA). In 6 chimpanzees infected HAV, anti-HA detected about first date elevated transaminases positive 3 months. usefulness confirmed testing acute phase sera 30 patients a common source outbreak epidemic hepatitis, negative 2 control groups. collection serum specimens 190 sporadic HBsAg-negative in Brazil also tested an etiologic association HAV majority these cases.
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