Complexes of hepatitis B surface antigen and immunoglobulin M in the sera of patients with hepatitis B virus infection.
作者： M Palla , R Rizzi , M Toti , P Almi , M Rizzetto
DOI: 10.1128/IAI.41.3.950-958.1983
关键词:
摘要: Hepatitis B surface antigen (HBsAg) bound to immunoglobulin M (IgM) was detected in sera of HBsAg carriers by a radioimmunoassay based on selective absorption the solid phase coated with antiserum human IgM. Isopycnic banding and rate-zonal sedimentation have shown that reaction is related particulate forms complexed The binding IgM possibly occurred because affinity these molecules particles. HBsAg/IgM found transiently 24 25 (96%) patients acute self-limited hepatitis persistently 6 whose progressed chronicity. It also 20 39 (51%) chronic inactive asymptomatic infection. phenomenon not dependent replication virions; its persistence may provide complementary evidence transition infection
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