Advances in the Control of Human Cutaneous Primary and Metastatic Melanoma by Thermal Neutron Capture Therapy
作者： Y. Mishima , M. Ichihashi , C. Honda , M. Shiono , T. Nakagawa
DOI: 10.1007/978-1-4615-3384-9_126
关键词: Amelanotic melanoma 、 Pathology 、 Delivery system 、 Metastatic melanoma 、 Metabolic activity 、 Melanoma 、 Cancer research 、 Medicine 、 Thermal neutron capture
摘要: Differing in principle from boron neutron capture therapy (NCT) of brain tumors using passive accumulation 10B, since 1972 our ideal) has been to develop a new 10B delivery system actively targeting cancers by utilizing their enhanced specific metabolic activity. As prototype, we have working with melanoma 10B1-p-boronophenylalanine (10B1-BPA), 10B-dopaanalogue, melanogenesis-seeking melanin polymer substrate2).
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