CD46 is a cellular receptor for human herpesvirus 6.
作者： Fabio Santoro , Paul E Kennedy , Giuseppe Locatelli , Mauro S Malnati , Edward A Berger
DOI: 10.1016/S0092-8674(00)81678-5
关键词: Virology 、 Immunology 、 Antibody 、 Downregulation and upregulation 、 Cell fusion 、 Biology 、 CD46 、 Human herpesvirus 6 、 Roseolovirus 、 Tropism 、 Exanthema Subitum
摘要: Human herpesvirus 6 (HHV-6) is the etiologic agent of exanthema subitum, causes opportunistic infections in immunocompromised patients, and has been implicated multiple sclerosis progression AIDS. Here, we show that two major HHV-6 subgroups (A B) use human CD46 as a cellular receptor. Downregulation surface was documented during course infection. Both acute infection cell fusion mediated by were specifically inhibited monoclonal antibody to CD46; also blocked soluble CD46. Nonhuman cells resistant entry became susceptible upon expression recombinant The ubiquitous immunoregulatory receptor opens novel perspectives for understanding tropism pathogenicity HHV-6.
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