Overview of the Tolerability Profile of Clarithromycin in Preclinical and Clinical Trials

摘要: Results of studies conducted to characterise local, systemic, reproductive, and mutagenic effects indicate that the new macrolide antimicrobial clarithromycin is well tolerated within reasonable multiples intended clinical dose. No adverse on male or female fertility, perinatal, postnatal reproduction were indicated by data from rabbits, mice, rats macaques. evidence potential was revealed various in vitro vivo study methodologies. Evidence low for ototoxicity, oculotoxicity, hepatotoxicity nephrotoxicity provided involving rats, dogs primates. In agreement with other macrolides, venous irritation intravenous lactobionate salt formulation substantial rabbit studies.