Erythromycin Ototoxicity: Analysis and Conclusions Based on 22 Case Reports

摘要: Although the majority of patients receiving erythromycin experience no hearing loss, certain are susceptible. Erythromycin ototoxicity data were analyzed on 20 from 13 reports in English language literature as well two University Missouri–Columbia. Patients classified with respect to age, sex, premorbid diagnosis, renal/hepatic function, type used, dosage, duration therapy, and route administration. The following auditory effects considered: onset symptoms, degree configuration recovery hearing. factors which, when combined use high-dose (≥2 gm/day), might place at risk for preexisting renal or hepatic disease, age (elderly), perhaps being female. With knowledge predisposing effects, clinician can more easily recognize loss caused by properly counsel referring physician...