Contemporary evidence on the physiological role of reactive oxygen species in human sperm function

摘要: Reactive oxygen species (ROS) play an important role in male fertility. Overproduction of reactive has been associated with a variety fertility complications, including leukocytospermia, varicocele and idiopathic infertility. The subsequent oxidative insult to spermatozoa can manifest as insufficient energy metabolism, lipid peroxidation DNA damage, leading loss motility viability. However, various studies have demonstrated that physiological amounts ROS roles the processes maturation, capacitation, hyperactivation acrosome reaction. It is therefore crucial define understand delicate balance reproductive cells tissues for better understanding both positive well negative impact production on fertilizing ability. This review will discuss specific roles, mechanisms action effects acquisition structural integrity activity spermatozoa.