Effect of a wheat amylase inhibitor on canine carbohydrate digestion, gastrointestinal function, and pancreatic growth

摘要: Abstract Background/Aims: Chronic amylase inhibition might be useful to treat diabetes mellitus and obesity. Duodenal ileal cannulas were placed in 8 dogs determine if long-term ingestion of a wheat inhibitor maintained or affected gastrointestinal metabolic function pancreatic growth. Methods: Five fed 3 not 1.5 g the with meals for 9 weeks. Postprandial cholecystokinin octapeptide stimulated secretion, fecal balance studies performed at intervals. After experiment, pancreas was analyzed. Results: Weight loss similar both groups. Amylase persisted throughout weeks; it declined from 91% 37% first sixth postprandial hour. decreased plasma glucose levels during hour ( P = 0.002), increased octapeptide-stimulated secretion. However, did significantly change concentrations insulin, peptide YY neurotensin, transit weight, protein DNA content. Conclusions: Prandial weeks reduces enough delay carbohydrate digestion absorption lower without altering This dose may effective but