Anti-tumor naphthoquinone formic acid soft analogues

摘要: A flexible analogue of the antineoplastic naphthoquinone acid in medical technological field is characterized that it comprises derivant II 6-substituent 5, 8-dimethoxyl-1, 4-naphthoquinone or III 2-substituent 4-naphthoquinone, which R stands for 5,8- dimethoxyl-1,4-naphthoquinone-6-formate 2- formate can be inverted by hydrolysis oxidizing metabolism; aldehydo, cyano, alkyl oxime, acidamide, carboxylate Ru¢-COOR1 methylol ester Ru¢-CH20COR1; R1 hydrogen atom with 1-9 carbon atoms saturated unsaturated aliphatic group aromatic group. The this invention used as antitumor agent. 5,8-dimethoxyl-1,4-naphthoquinone-6-formate 2-formate human body synthesized said design translates into corresponding free cell toxic action to reduce toxicity.