Chemical inhibitor of p53-snail binding and pharmaceutical composition for treating cancer disease containing same as its active ingredient
作者： Jee Hyun Lee , Gyu Yong Song , Bum Joon Park , Nam Chul Ha , Sun Hye Lee
DOI:
关键词:
摘要: The present invention relates to a chemical inhibitor of p53-Snail binding and pharmaceutical composition for treating cancer diseases containing the same as its active ingredient. induces expression p-53 in K-Ras mutant cell lines, thus can effectively treat or prevent that may not be easily diagnosed treated, such pancreatic cancer, lung cholangioma, colon cancer.
lens.org 参考文章(9)
2-Substitiuted Thio- and Amino-5,8-dimethoxy-1,4-naphthoquinones as a Novel Class of Acyl-CoA: Cholestrol Acyltransferase Inhibitors Bulletin of The Korean Chemical Society. ,vol. 30, pp. 1088- 1092 ,(2009) , 10.5012/BKCS.2009.30.5.1088
Sun-Hye Lee, Su-Jin Lee, Yeon Sang Jung, Yongbin Xu, Ho Sung Kang, Nam-Chul Ha, Bum-Joon Park, Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function. Neoplasia. ,vol. 11, pp. 22- 31 ,(2009) , 10.1593/NEO.81006
Sean O'brien, Jiemin Lu, Janak K. Padia, Stanislaw Pikul, Diamine derivatives of quinone and uses thereof ,(2004)
Jean F. Grollier, Jean Cotteret, Composition based on quinone dyestuffs for use in hair dyeing and process for the preservation of quinone dyestuffs ,(1992)
Rajeshwar P. Verma, Corwin Hansch, Elucidation of structure-activity relationships for 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones. Bioorganic & Medicinal Chemistry. ,vol. 12, pp. 5997- 6009 ,(2004) , 10.1016/J.BMC.2004.08.017
Wei Guo, Shuhong Wu, Jinsong Liu, Bingliang Fang, Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota Cancer Research. ,vol. 68, pp. 7403- 7408 ,(2008) , 10.1158/0008-5472.CAN-08-1449
Product Class 3: Naphtho-1,4-quinones Georg Thieme Verlag. ,(2006) , 10.1055/SOS-SD-028-00226
Li Shaoshun Xie, Anti-tumor naphthoquinone formic acid soft analogues ,(2006)
Ricardo A. Tapia, Miriam C. Gárate, Jaime A. Valderrama, Paul R. Jenkins, SYNTHESIS OF FURANONAPHTHAZARIN DERIVATIVES Heterocycles. ,vol. 48, pp. 1365- 1371 ,(1998) , 10.3987/COM-98-8118