Long non-coding RNA THOR promotes cell proliferation and metastasis in hepatocellular carcinoma.

摘要: Abstract Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in the development and progression of multiple cancers by previous studies. Recently, a novel lncRNA, THOR (testis-associated highly conserved oncogenic long RNA), was characterized human shown exhibit an role. However, role hepatocellular carcinoma (HCC) is still unclear. In this study, we found that relatively expressed HCC tissues cell lines. Notably, high expression associated with worse prognosis. depletion resulted significant inhibition growth metastasis cells. Mechanistically, drives via PTEN/AKT pathway. Moreover, specific PI3-K inhibitor LY294002 abolished discrepancy metastatic capacity between THOR-silenced cells control cells, which further confirmed AKT required THOR-driven metastasis. Taken together, our results suggest could promote amplifying signaling may new therapeutic target predictive factor for HCC.