APPRAISAL OF THE HYPOTHESIS OF THE “DEPOLARIZATION-INDUCED” RELEASE OF CALCIUM FROM THE SARCOPLASMIC RETICULUM IN SKINNED CARDIAC CELLS FROM THE RAT OR PIGEON VENTRICLE

摘要: Publisher Summary This chapter discusses the depolarization-induced release of calcium ions (Ca2+) from cardiac SR and describes more recent experiments thoroughly testing effect replacement potassium propionate (K+P-) with choline chloride (Ch+Cl-). It presents reports that were obtained various types preparations rat ventricle. These included skinned cells by microdissection, groups 2–6 sarcolemma disrupted homogenization without skinning microdissection multi-cellular about 50 μn diameter had been chemically EGTA. In addition, some done in frog skeletal muscle fibers, either Natori's technique or homogenization. Various stability constants used to compute free ion concentrations these early studies. earliest experiments, no computations at all done. Yet, information including total contamination solution was available.