Serum melatonin level and oxidative stress in sickle cell anemia.
作者： Eliana Litsuko Tomimatsu Shimauti , Danilo Grunig Humberto Silva , Eduardo Alves de Almeida , Paula Juliana Antoniazzo Zamaro , Edis Belini Junior
DOI: 10.1016/J.BCMD.2010.08.013
关键词: Anemia 、 Melatonin 、 Lipid peroxidation 、 Endocrinology 、 Trolox equivalent antioxidant capacity 、 Internal medicine 、 Sickle cell anemia 、 Antioxidant 、 TBARS 、 Oxidative stress 、 Immunology 、 Medicine
摘要: This study evaluated serum melatonin levels in patients with sickle cell anemia (SCA) and compared the results to lipid peroxidation by determining thiobarbituric acid-reactive substances (TBARS) Trolox equivalent antioxidant capacity (TEAC). The group studied was composed of 15 SCA 24 subjects without hemoglobinopathies. average level significantly reduced (p<0.001) when control group. showed higher values for TBARS TEAC obtained (p<0.001 p<0.01). Results from correlation analysis were not statistically significant any parameters except levels, which had a positive (r=0.51; p=0.04), suggesting participation defense. use could be possible therapeutic target improving defense reduce oxidative damage, alleviating symptoms associated SCA.
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