The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis.

作者: Zehra Akpınar , Serhat Tokgöz , Hakkı Gökbel , Nilsel Okudan , Faruk Uğuz

DOI: 10.1016/J.PSYCHRES.2007.11.022

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摘要: Abstract The association of nocturnal serum melatonin levels was investigated in acute multiple sclerosis (MS) patients with major depression (MD). sample comprised 13 MD and 12 no psychiatric disorders admitted to our clinic due MS attacks. Psychiatric evaluation performed the Structured Clinical Interview for DSM-IV (SCD-I). level depressive symptoms assessed Beck Depression Scale (BDS). Blood samples were taken from determine at 03.30h 10.00h before steroid treatment started. Melatonin determined using ELISA test. Nocturnal (21.2 ± 17.1 pg/ml) significantly lower than those (51.5 ± 18.3 pg/ml) without MD. A significant negative correlation found between BDS scores levels. These findings suggest that a deficiency may be among factors involved occurence patients.

参考文章(25)
Stephan A. Mayer, Elan D. Louis, H. Houston Merritt, Lewis P. Rowland, Merritt's Neurology ,(2001)
Johan Beck-Friis, Dietrich von Rosen, Bengt F. Kjellman, Jan-Gustaf Ljunggren, Lennart Wetterberg, Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects Psychoneuroendocrinology. ,vol. 9, pp. 261- 277 ,(1984) , 10.1016/0306-4530(84)90005-2
Chris H Polman, Jerry S Wolinsky, Stephen C Reingold, Multiple sclerosis diagnostic criteria: three years later Multiple Sclerosis Journal. ,vol. 11, pp. 5- 12 ,(2005) , 10.1191/1352458505MS1135OA
Frédéric Fanget, Bruno Claustrat, Jean Dalery, Jocelyne Brun, Jean-Louis Terra, Michel Marie-Cardine, Jean Guyotat, Nocturnal plasma melatonin levels in schizophrenic patients Biological Psychiatry. ,vol. 25, pp. 499- 501 ,(1989) , 10.1016/0006-3223(89)90205-9
Reuven Sandyk, Gavin I. Awerbuch, Nocturnal Melatonin Secretion in Multiple Sclerosis Patients with Affective Disorders International Journal of Neuroscience. ,vol. 68, pp. 227- 240 ,(1993) , 10.3109/00207459308994278
Andrew Miles, David R.S. Philbrick, Melatonin and psychiatry Biological Psychiatry. ,vol. 23, pp. 405- 425 ,(1988) , 10.1016/0006-3223(88)90291-0
Robert T. Rubin, Neuroendocrine Aspects of Primary Endogenous Depression Archives of General Psychiatry. ,vol. 49, pp. 558- 567 ,(1992) , 10.1001/ARCHPSYC.1992.01820070052008
J. F. Smyth, Progress in Clinical and Biological Research Journal of Clinical Pathology. ,vol. 32, pp. 742- 742 ,(1979) , 10.1136/JCP.32.7.742-D
Reuven Sandyk, Gavin I Awerbuch, Nocturnal melatonin secretion in suicidal patients with multiple sclerosis International Journal of Neuroscience. ,vol. 71, pp. 173- 182 ,(1993) , 10.3109/00207459309000602
ANITA CAVALLO, KAY G. HOLT, MASOUD S. HEJAZI, GAIL E. RICHARDS, WALTER J. MEYER, Melatonin circadian rhythm in childhood depression. Journal of the American Academy of Child and Adolescent Psychiatry. ,vol. 26, pp. 395- 399 ,(1987) , 10.1097/00004583-198705000-00020