Neuroendocrine Aspects of Primary Endogenous Depression

摘要: • To ascertain the extent of dysregulation melatonin secretion in endogenous depression, we measured nocturnal and diurnal serum concentrations 38 depressed patients (23 women 15 men) who had primary, definite depression according to Research Diagnostic Criteria individually matched normal control subjects. Previous reports have suggested that such may reduced secretion, often conjunction with increased hypothalamicpituitary-adrenal cortical axis activity. This has been considered as a possible reflection noradrenergic activity depression. Compared their controls, showed trend toward significantly elevated average concentration was accounted for primarily by 14 premenopausal women—the postmenopausal female male depressive did not differ from respective controls. The also being higher both patients. measures were consistently related any previously reported hypothalamic-pituitary-adrenal these Our findings thus failed confirm "low syndrome" or an inverse relationship between cortisol discrepancy be methodologic differences among studies; our data are accord those one other study which controls on variables known influence secretion. Most studies, including ours, cross-sectional. However, few longitudinal studies date found consistent profiles same when they euthymic manic.