Nocturnal melatonin secretion in suicidal patients with multiple sclerosis

摘要: Multiple sclerosis (MS) is characterised by the occurrence of patchy CNS demyelinating lesions, leading to various degrees motor, sensory, affective, and cognitive deficits. MS associated also with an increased risk suicide accounting for a substantial rate death among these patients. Post-mortem studies in victims psychiatric disorders demonstrate decreased concentration serotonin (5-HT) its metabolites brain. Since 5-HT precursor synthesis melatonin as pineal content was found be low victims, we predicted lower secretion suicidal versus non-suicidal patients during acute exacerbation symptoms. To test this hypothesis, investigated nocturnal plasma levels cohort 28 relapsing who were admitted consecutively inpatient Neurology service, 6 whom had history attempts having ideation at time admission. While both cohorts o...