Pineal calcification and its relationship to the fatigue of multiple sclerosis.

摘要: Fatigue is one of the most common clinical features multiple sclerosis (MS) and a frequent cause disability. The pathogenesis fatigue remains obscure. It may result from impaired propagation action potentials in areas demyelination. Other contributors be mental depression, immobility, physical MS relieved by diverse pharmacological drugs such as amantadine pemoline, but mechanisms which these agents act to ameliorate are unknown. Attention has been focused recently on relationship between pineal gland evidence presented implicate melatonin disease. To investigate this further, we studied 47 patients (mean age: 41.6 +/- 9.9 yrs; mean duration illness: 13.6 12.6 yrs) association incidence calcification (PC) CT scan, thought reflect past secretory activity gland. For comparison, also evaluated choroid plexus (CPC) patients. sample included 20 who experienced ongoing, debilitating during course 27 did not complain served controls. two groups were distinguishable with respect age, sex, age onset, chronicity, (relapsing-remitting vs. chronic progressive), severity disease (ambulatory immobile), well affective illness.(ABSTRACT TRUNCATED AT 250 WORDS)