Is pesticide exposure a cause of obstructive airways disease
作者： E. Doust , J. G. Ayres , G. Devereux , F. Dick , J. O. Crawford
DOI: 10.1183/09059180.00005113
关键词: Systematic review 、 Medicine 、 Confounding 、 COPD 、 CINAHL 、 Asthma 、 Incidence (epidemiology) 、 Environmental health 、 Pesticide 、 Toxicology 、 MEDLINE
摘要: A systematic review was performed to identify any associations between pesticide exposure and the occurrence (both prevalence incidence) of airways disease (asthma chronic obstructive pulmonary disease) wheezing symptoms. PubMed, MEDLINE, Embase, Scopus, CINAHL, Google Scholar Cochrane Database Systematic Reviews were searched September 2010 October for papers with inclusion criteria English language, published after 1990, peer-reviewed nondietary exposure. From a total 4390 identified, 42 included initial assessment content. After evaluating studies quality, those considered be at high risk bias excluded, leaving 23 relevant papers. Results suggest that pesticides may associated prevalent asthma, but methodological issues, such as cross-sectional/case–control design, measurements limited adjustment confounders, limit strength evidence base in this area. The association asthma appears more evident consistent children than adults. Exposure COPD; however, an COPD is weaker asthma. As metrics within each health end-point varied across studies, no meta-analyses carried out.
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