作者: Lilian Ricaud , Caroline Proux , Jean-Pierre Renou , Olivier Pichon , Sylvain Fochesato
DOI: 10.1371/JOURNAL.PONE.0000430
关键词: Genetics 、 DNA repair 、 Cell cycle 、 Cell growth 、 Ataxia-telangiectasia 、 Transcriptional regulation 、 Chromatin 、 Regulation of gene expression 、 Cellular differentiation 、 Biology 、 Cell biology
摘要: ATM (Ataxia Telangiectasia Mutated) is an essential checkpoint kinase that signals DNA double-strand breaks in eukaryotes. Its depletion causes meiotic and somatic defects in …