Ultrasound findings and multiple marker screening in trisomy 18.
作者： C Brumfield
DOI: 10.1016/S0029-7844(99)00461-5
关键词: Ultrasound 、 Down syndrome 、 Confidence interval 、 Gynecology 、 Aneuploidy 、 Pregnancy 、 Choroid plexus cyst 、 Medicine 、 Gestation 、 Trisomy
摘要: Abstract Objective: To compare detection of trisomy 18 in the second trimester by ultrasound and multiple-marker testing. Methods: A computerized genetics database was used to identify fetuses 14–22 weeks’ gestation who had comprehensive examinations, screening tests (alpha-fetoprotein [AFP]), hCG, unconjugated estriol [E3], karyotype. positive screen defined as AFP up 0.75 multiples median (MoM), hCG 0.55 MoM, E3 0.60 MoM. risk at least 1:190 a Down syndrome screen. Ultrasound abnormalities were diagnosed prospectively confirmed later retrospective review sonographic images. Results: From 1988–1997, 30 ultrasounds testing identified. Twenty-one (70%) detected ultrasound, which most common isolated finding choroid plexus cyst. Eleven (37%) screens, two for total 13 (43%) with tests. Conclusion: We found that more likely be abnormal than (95% confidence interval [CI] 54, 86 versus 43% CI 25, 61). However, combining methods yielded highest rate (80% [CI 66%, 94%]).
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