Choroid plexus cysts and trisomy 18: Risk modification based on maternal age and multiple-marker screening

摘要: Abstract Choroid plexus cysts are more common in fetuses with chromosomal aneuploidies, particularly trisomy 18. Although it is accepted that the risk of karyotypic abnormality justifies amniocentesis when associated abnormalities present, disagreement continues as to 18 a fetus an isolated choroid cyst. We propose consideration maternal age and multiple-marker screening for aneuploidy assessment risk. Bayesian statistical modeling was used calculate from age-related figures incidence The further modified on basis ability detect From estimates calculated across ages 20 45 years, does not approach until ≥37 years. Therefore presence cyst normal screen results justified only patient advanced age. (Am J Obstet Gynecol 1996;175:1493-7.)