Isolated fetal choroid plexus cysts and trisomy 18: A review and meta-analysis

摘要: Abstract OBJECTIVE: Risk of trisomy 18 in a fetus with ultrasonographic diagnosis choroid plexus cysts and no other anomalies is controversial. Using our data current literature, we performed meta-analysis estimated the positive predictive value isolated fot risomy 18. STUDY DESIGN: Between Jan. 1, 1989, Dec. 31, 1992, all women undergoing examination at institution were prospectively evaluated for fetal cytogenetic outcome. In addition, reports dealing obtained from MEDLINE (1983 through 1992) assessed. Only prospective studies > 10 cases further to determine total number fetuses otherwise normal sonograms. Frequency aneuploidy was determined by analysis included studies. To estimate 18, theoretic 2 × table constructed values available literature. RESULTS: Eighty identified unit. Of 74 cysts, there Meta-analysis among 748 (1374). derive reviewed literature found 50 who underwent midtrimester. There 3 12 (24%) had results. midtrimester incidence 1 2461 (Hsu LYF. In: Milunsky A, ed. Genetic disorders fetus. 3rd Baltimore: Johns Hopkins University Press, 1992:155–210; Hook et al. Am J Hum Genet 1989;1945:855–861 prenatal prevalence 0.95% (based on review literature), 390. CONCLUSION: On basis risk (1374) its close approximation (1390), do not support routine offering invasive testing cysts.