Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.
作者： Zhao Wu , Wei Zhang , Guibin Chen , Lu Cheng , Jing Liao
关键词: Embryonic stem cell 、 Cell fate commitment 、 Activin type 2 receptors 、 Cell biology 、 Trophoblast 、 Biology 、 Genetics 、 Nodal signaling 、 Inner cell mass 、 TGF beta signaling pathway 、 NODAL
摘要: Cell fate commitment of pre-implantation blastocysts, to either the inner cell mass or trophoblast, is first step in lineage segregation developing human embryo. However, intercellular signals that control determination these cells remain obscure. Human embryonic stem (hESCs) provide a unique model for studying early development. We have previously shown Activin/Nodal signaling contributes maintaining pluripotency hESCs, which are derivatives mass. Here we further demonstrate inhibition results loss hESC and trophoblast differentiation, similar BMP4-induced differentiation from hESCs. also show induction effect BMP4 correlates with depends on signaling. activation BMP still required when inhibited. These data reveal hESCs determined by combinatorial BMP.
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