The pharmacological properties of fibrinogen degradation products
作者： KAROL BULUK , MICHAŁ MAŁOFIEJEW
DOI: 10.1111/J.1476-5381.1969.TB07968.X
关键词: Renin–angiotensin system 、 Acetylcholine 、 Muscle contraction 、 Internal medicine 、 Norepinephrine (medication) 、 Bradykinin 、 Chemistry 、 Histamine 、 Plasmin 、 Kallidin 、 Endocrinology
摘要: Abstract 1. A method of obtaining partially purified products plasmin degradation fibrinogen (F.D.P.) is described. The F.D.P. passes through dialysing tubes and does not lose its activity during heating for 15 min at a temperature 56° C. 2. In experiments on isolated organs, in small doses potentiates the contractile action bradykinin, kallidin, angiotensin, histamine, 5-hydroxy-tryptamine, acetylcholine, adrenaline noradrenaline. high concentrations, induces an increase initial tonus smooth muscles simultaneously lowers sensitivity to pharmacologically active substances mentioned. 3. similarity effect different concentrations KCl reaction guinea-pig intestine constant histamine bradykinin observed. 4. hypothesis presented that amines polypeptides larger increases these by changing concentration cell electrolytes.
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