Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells.

摘要: Lamotrigine is a chemically novel anticonvulsant drug that has been reported to inhibit veratrine-induced neurotransmitter release from cortical slices in vitro. To characterize further the mechanism of action lamotrigine, we have investigated effects this together with drugs phenytoin and carbamazepine on voltage-sensitive sodium channels present N4TG1 mouse neuroblastoma clonal cells. Lamotrigine, produced tonic inhibition IC50 values 91, 58 140 microM, respectively. At concentration 100 all compounds shifted voltage-dependency steady-state inactivation toward more negative potentials by 7 15 mV, slowed rate recovery use-dependent channels. Our data show lamotrigine inhibits manner similar carbamazepine. This neuronal activity consistent reduction glutamate was previously neurochemical studies, it expands our understanding drug.