Appropriate collimators in a small animal SPECT scanner with CZT detector.

作者: Yusuke Higaki , Masato Kobayashi , Tomoya Uehara , Hirofumi Hanaoka , Yasushi Arano

DOI: 10.1007/S12149-012-0681-5

关键词: Nuclear medicinePinhole (optics)Image resolutionScannerCollimatorSmall animalSpect imagingImage qualityPlanar ImagingMedicine

摘要: Almost all small animal SPECT is performed with pinhole collimators (PH), including single-PH (SPH) and multi-PH (MPH). In the clinical study, not only PH but also parallel-hole collimator (PAH) often used in planar imaging. However, there have been no comparative studies on image quality various This study compared basic characteristics of PAH Performance images was evaluated using 99mTcO4 − SPH, MPH low energy high resolution SPECT/CT scanner FX3200. We measured sensitivity, resolution, concentration linearity uniformity. Planar imaging mice 99mTc-labeled mercaptoacetyltriglycine (99mTc-MAG3) SPH PAH. 99mTc-methylene diphosphonate (99mTc-MDP) collimators. With PAH, sensitivity 43.5, 211.2 926.5 cps/MBq, respectively, spatial 0.60/0.56, non/0.96, 5.20/5.34 mm full-width half maximum (planar/SPECT), respectively. There were marked correlations between radioactivity counts Values % standard deviation showed differences while values smallest MPH. On mice, yielded high-quality 99mTc-MAG3-planar when sharper 99mTc-MDP-SPECT than The differed Although higher resolution. Among collimators, more appropriate for imaging, suitable a CZT detector.

参考文章(20)
T. Funk, K.B. Parnham, B.E. Patt, J. Li, J.S. Iwanczyk, K. Iwata, A.B. Hwang, B.H. Hasegawa, A new CdZnTe-based gamma camera for high resolution pinhole SPECT ieee nuclear science symposium. ,vol. 4, pp. 2320- 2324 ,(2003) , 10.1109/NSSMIC.2003.1352361
Hyunki Kim, Lars R. Furenlid, Michael J. Crawford, Donald W. Wilson, H. Bradford Barber, Todd E. Peterson, William C. J. Hunter, Zhonglin Liu, James M. Woolfenden, Harrison H. Barrett, SemiSPECT: A small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays Medical Physics. ,vol. 33, pp. 465- 474 ,(2006) , 10.1118/1.2164070
Y. Zingerman, H. Golan, A. Gersten, A. Moalem, A compact CT/SPECT system for small-object imaging Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 584, pp. 135- 148 ,(2008) , 10.1016/J.NIMA.2007.09.025
John Roberts, Bo Chen, Lisa M. Curtis, Anupam Agarwal, Paul W. Sanders, Kurt R. Zinn, Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury American Journal of Physiology-renal Physiology. ,vol. 293, ,(2007) , 10.1152/AJPRENAL.00083.2007
C Scheiber, CdTe and CdZnTe detectors in nuclear medicine Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 448, pp. 513- 524 ,(2000) , 10.1016/S0168-9002(00)00282-5
Greta S. P. Mok, Jianhua Yu, Yong Du, Yuchuan Wang, Benjamin M. W. Tsui, Evaluation of a multi-pinhole collimator for imaging small animals with different sizes. Molecular Imaging and Biology. ,vol. 14, pp. 60- 69 ,(2012) , 10.1007/S11307-011-0472-8
Jianguo Qian, Eric L. Bradley, Stan Majewski, Vladimir Popov, Margaret S. Saha, Mark F. Smith, Andrew G. Weisenberger, Robert E. Welsh, A small-animal imaging system capable of multipinhole circular/helical SPECT and parallel-hole SPECT. Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 594, pp. 102- 110 ,(2008) , 10.1016/J.NIMA.2008.05.061
Keiichi Magota, Naoki Kubo, Yuji Kuge, Ken-ichi Nishijima, Songji Zhao, Nagara Tamaki, Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 38, pp. 742- 752 ,(2011) , 10.1007/S00259-010-1683-Y
Tanja Herrler, Hao Wang, Anne Tischer, Peter Bartenstein, Karl-Walter Jauch, Markus Guba, Markus Diemling, Cyril Nimmon, Marcus Hacker, 99mTc-MAG3 scintigraphy for the longitudinal follow-up of kidney function in a mouse model of renal ischemia-reperfusion injury EJNMMI research. ,vol. 2, pp. 2- 2 ,(2012) , 10.1186/2191-219X-2-2
Izumi O. Umeda, Kotaro Tani, Keisuke Tsuda, Masamitsu Kobayashi, Mayumi Ogata, Sadaaki Kimura, Mitsuyoshi Yoshimoto, Shuji Kojima, Kunikazu Moribe, Keiji Yamamoto, Noriyuki Moriyama, Hirofumi Fujii, High resolution SPECT imaging for visualization of intratumoral heterogeneity using a SPECT/CT scanner dedicated for small animal imaging. Annals of Nuclear Medicine. ,vol. 26, pp. 67- 76 ,(2012) , 10.1007/S12149-011-0542-7