Supramolecular hydrogels based on short peptides linked with conformational switch.
作者： Yucheng Huang , Zhenjun Qiu , Yanmei Xu , Junfeng Shi , Hongkun Lin
DOI: 10.1039/C0OB01057J
关键词: Salt effect 、 Supramolecular chemistry 、 Amino acid 、 Side chain 、 Supramolecular hydrogels 、 Cationic polymerization 、 Stereochemistry 、 Light irradiation 、 Chemistry 、 Azobenzene
摘要: Short peptides appropriately linked with an azobenzene conformational switch were found to be motif and pH dependant supramolecular hydrogelators. The hydrogelation properties of the short studied in detail respect dependence on amino acid residue, salt effect. presence acids aromatic side chains such as Phe Tyr was favorable for gel water at appropriate range. Cationic residues Arg Lys unfavorable hydrogelation. effect also important factors peptides. A series bioactive sequences their investigated. Photoresponsive hydrogels realized based E-/Z- transition upon light irradiation. Proper combination resulted smart responses multiple stimuli.
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