Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice.
作者： Tarja M. Malm , Milla Koistinaho , Maria Pärepalo , Tero Vatanen , Andreas Ooka
DOI: 10.1016/J.NBD.2004.09.009
关键词: Inflammation 、 Transplantation 、 Microglia 、 Gliosis 、 Cellular differentiation 、 Pathology 、 Bone marrow 、 Genetically modified mouse 、 Biology 、 Immunology 、 Transgene
摘要: … The parental APP695Swe and PS1 (A246E) mice were backcrossed 13–14 generations to … to create double transgenic mouse line (APP + PS1 mice). Four APP + PS1 mice died during …
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